Vivien Ho

Health tech's last five years laid its foundation; the next five will change the game entirely. We at Define Ventures took a hard look at our sector because we wanted to dive into the real story. Whether we looked at venture funding, relative sector performance, public market trends, or M&A, we found that health tech has performed quite well over its early years in light of the evolution and change during our recent history. And more importantly, that the next wave of companies defining it are doing so in unprecedented fashion: * They’re scaling faster. Companies expected to pursue liquidity events over the coming years are reaching 2-3x the revenue scale of previous exits. * They’re building more efficiently. AI and automation are making commercialization faster and less capital​ intensive * They’re meeting a more receptive buyer market. Payers, providers, employers​, and pharma are more equipped to adopt new solutions than they were even five years ago ​ We believe this is a defining moment for ​h​ealth tech. The companies emerging today won’t just digitize healthcare— they ​w​ill fundamentally rethink how care is delivered, paid for, and experienced. Our latest report unpacks what this means for founders, investors, and the healthcare ecosystem at large:

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Omada Health, which went public three months ago, just released promising results: more than 60% of its members maintained weight loss after discontinuing GLP-1 therapy. I wrote down a few thoughts. 1️⃣ 𝐔𝐧𝐭𝐢𝐥 𝐫𝐞𝐜𝐞𝐧𝐭𝐥𝐲, 𝐇𝐞𝐚𝐥𝐭𝐡𝐓𝐞𝐜𝐡 𝐈𝐏𝐎𝐬 𝐰𝐞𝐫𝐞 𝐚 𝐛𝐥𝐨𝐨𝐝𝐛𝐚𝐭𝐡 Over 90% of HealthTech companies (including TechBio) that went public have significantly underperformed. Halle Tecco analyzed 23 digital health SPACs (around 40% of all HealthTech public listings went through SPACs). Her findings: ▪️30% declared bankruptcy ▪️26% were acquired at steep losses ▪️90% of those still trading have lost double-digit value since debut But now, it seems this dynamic may finally be shifting. 2️⃣ 𝐓𝐞𝐦𝐩𝐮𝐬, 𝐖𝐚𝐲𝐬𝐭𝐚𝐫, 𝐇𝐢𝐧𝐠𝐞, 𝐎𝐦𝐚𝐝𝐚 = 𝐫𝐞𝐚𝐥 𝐮𝐧𝐢𝐜𝐨𝐫𝐧𝐬 As of September 9, 2025, their market capitalizations were: Tempus AI = $14B Waystar = $7B Hinge Health = $4.5B Omada Health = $1.4B For comparison: Philips, the leading MedTech, has a market cap of $23B. Tempus is going straight after Philips. 3️⃣ 𝐁𝐞𝐜𝐨𝐦𝐢𝐧𝐠 𝐝𝐢𝐬𝐭𝐫𝐢𝐛𝐮𝐭𝐨𝐫𝐬 Last year, Hinge Health launched its Strategic Solutions Alliance, which now includes 13 partners whose solutions can be distributed directly to Hinge Health’s member base. This is a more generic pattern: once a HealthTech has gained a strong installed base through its point solution, it becomes a curated marketplace. 4️⃣ 𝐓𝐞𝐦𝐩𝐮𝐬 𝐢𝐬 𝐭𝐫𝐚𝐧𝐬𝐟𝐨𝐫𝐦𝐢𝐧𝐠 𝐜𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐜𝐚𝐫𝐞 𝐢𝐧 𝐨𝐧𝐜𝐨𝐥𝐨𝐠𝐲 𝐚𝐧𝐝 𝐛𝐞𝐲𝐨𝐧𝐝 Tempus AI secured the first AI-only CPT reimbursement code in the US (October 2024). It also acquired Page AI, a leader in digital pathology. After oncology, Tempus aims to expand into cardiology, neurology, and psychiatry. 5️⃣ 𝐁𝐞𝐲𝐨𝐧𝐝 𝐈𝐏𝐎𝐬: 𝐬𝐭𝐫𝐨𝐧𝐠 𝐌&𝐀 𝐚𝐜𝐭𝐢𝐯𝐢𝐭𝐲, 𝐞𝐬𝐩𝐞𝐜𝐢𝐚𝐥𝐥𝐲 𝐢𝐧 𝐧𝐨𝐧-𝐜𝐥𝐢𝐧𝐢𝐜𝐚𝐥 HealthEdge, a CareOps player, was acquired by Bain Capital for $2.6B (May 2025) Arcadia, a #healthcare analytics company, was acquired by Nordic Capital for an undisclosed sum (June 2025) Iodine Software (AI-powered healthcare payments) was acquired by Waystar (July 2025) Some HealthTech companies are now mature enough for private equity, while winners like Waystar are consolidating the market. 6️⃣ 𝐄𝐮𝐫𝐨𝐩𝐞 = 𝟎 𝐈𝐏𝐎 While the US (and China) already count dozens of HealthTech #IPOs, Europe has had none. Doctolib could be the first next year… or perhaps Alan. --------- This analysis was made possible by the HealthTech Alpha platform from Galen Growth | Redefining Digital Health Intelligence. Join the Healthcare Business International conference in March 2026 in Paris for more M&A in Healthcare Innovation discussions! Follow HGM Advisory for daily reposts of the most relevant #HealthTech news.

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Thrilled to announce Greenfield Partners' lead investment in Eleos Health's $60M Series C! From our first meeting with Alon Joffe and team, their vision for transforming behavioral healthcare deeply resonated with us. The challenge is clear: by 2030, we're facing a 4.5M clinician shortage in mental health. What impressed us most was Eleos's practical, innovative approach to this crisis - using AI not to replace clinicians, but to dramatically expand their capacity to deliver care. The results speak for themselves - over 120 healthcare organizations across 30+ states are already seeing documentation time cut in half. But what truly excites me is the road ahead. We're already working closely with the Eleos team under the leadership of our Operating Partner Nir Goldstein, implementing our seven-pillar GTM framework to accelerate their growth with efficiency. To Alon Joffe, Dror Zaide, Alon Rabinovich, and the entire Eleos team - congratulations on this milestone! The behavioral health space needs your innovation now more than ever, and we at Greenfield couldn't be more excited to partner with you on this journey. Looking forward to supporting your mission of empowering clinicians to focus on what matters most - delivering exceptional patient care. Itay Inbar, Nir Goldstein

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