Take your guesses for #ASHSlideSaturday 🩸! This post is part of the Rare Diseases Educational Series, developed by the American Society of Hematology and supported by Alexion. #ASHEducation #Microlearning #Microscopy #ImageChallenge #Hematology #Hematopathology #ASHTrainee #LearningIsFun #KnowledgeIsPower #LearnGrowEvolve #RareDiseases #Alexion
Plasma cell leukemia?
Haemophagocytosis
Hemophagocytosis
In this week’s bone-marrow aspiration slide a macrophage is clearly phagocytosing hematopoietic elements. this morphologic ➡️ an important clue, it is not by itself diagnost. The diagnosis requires clinicopathologic synthesis (or molecular confirmation) and is generally made when established criteria are met. Patients with HLH most commonly present with a constellation of findings including fever, cytopenias (often affecting ≥2 lineages), splenomegaly, coagulopathy/bleeding tendency, hypertriglyceridemia, and marked hyperferritinemia; these features should prompt urgent evaluation because HLH can progress rapidly without treatment. In adults, secondary (acquired) HLH is frequently triggered by underlying pathology. Malignancy, especially lymphoproliferative disorders, accounts for a large proportion of adult cases, and rheumatologic disease , primary or opportunistic infections, and immune-suppressing conditions are also important causes to consider. Viral infections are among the most common infectious triggers (notably EBV, but also CMV, VZV, parvovirus B19, HHV-8, HIV and, in selected reports, severe SARS-CoV-2 infection), and identifying a trigger is critical both for prognosis and tailored management.